Prekurzorové léze adenokarcinomu žaludku
作者： Bohuslava Šašková , Ondřej Daum , Magdaléna Dubová , Kristýna Pivovarčíková , Marián Švajdler
关键词:
摘要: Přehledový clanek shrnuje klinicke a patologicke charakteristiky lezi považovaných za prekurzorove leze adenokarcinomu žaludku. Patogeneze karcinomu žaludku je multifaktorialni proces, v kterem hraji významnou ulohu geneticke environmentalni faktory. Intestinalni typ nejcastěji vznika sekvenci změn, ktera zacina chronickou gastritidou, pokracuje atrofii sliznice jeji intestinalni metaplazii přes stadium dysplastických změn progreduje do adenokarcinomu. Meně castými prekurzorovými lezemi jsou foveolarni dysplazie (nebo tzv. adenom), adenom z pylorických žlazek, postihujici sliznicni krypty („pit/crypt“ dysplasia), polyp fundických hyperplastický tež některe nenadorove hamartogenni polypy. Prekurzorove difuzniho typu (karcinom prstencitých buněk in situ pagetoidni siřeni buněk) možne zastihnout jen u casti pacientů s mutaci CDH1.
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