The impact of AIDS diagnoses on long-term neurocognitive and psychiatric outcomes of surviving adolescents with perinatally acquired HIV.

摘要: Objective: To explore the association between previous severe HIV disease, defined as past Centers for Disease Control and Prevention class C diagnosis, neurocognitive psychiatric outcomes in long-term survivors of perinatally acquired HIV. Design: A retrospective cohort study HIV-infected adolescents receiving outpatient care at a single site. Methods: Comparisons were made those with without diagnoses. Results: Eighty-one patients formed group, 47% females 72% African‐American.Medianpatientagewas15years(interquartilerange13‐17).Ofthe had diagnosis. The median age diagnosis was 3.1 years (interquartile range 0.9‐8.1). There no significant differences groups respect to most recent CD4 þ cell percentage or plasma viral RNA level. Class more likely have history [odds ratio 2.6; 95% confidence interval (CI) 1.1‐6.3], hospitalization (odds 4.8; CI 1.2‐17.4), learning disability 4.5; 1.7‐11.4). difference full-scale intelligence quotient (adjusted linear regression coefficient � 11.7; 17.9 5.5). After adjusting antiretroviral therapy initiation, associations lower quotient, disorders, diagnoses remained significant. Conclusion: AdistanthistoryofAIDSdiagnosiswasassociatedwithanincreasedriskof impairment Further research should help delineate if early treatment, possibly soon after birth definitely prior AIDS might lead improved outcomes. 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins 2009, 23:1859‐1865