Prediction of Shear Induced Platelet Activation in Prosthetic Heart Valves by Integrating Fluid–Structure Interaction Approach and Lagrangian-Based Blood Damage Model

摘要: Altered haemodynamics are implicated in the blood cells damage that leads to thromboembolic complications presence of prosthetic cardiovascular devices, with platelet activation being underlying mechanism for cardioemboli formation flow past mechanical heart valves (MHVs). Platelet can be initiated and maintained by patterns arising from flowing through MHV, lead an enhancement aggregation platelets, increasing risk thromboemboli formation. Hellums colleagues compiled numerous experimental results depict a locus incipient shear related on stress – exposure time plane, commonly used as standard threshold [1]. However, is significantly greater under pulsatile or dynamic condition relative constant [2]. Previous studies do not allow determine relationship existing between measured effect — platelet, cause time-varying loading, it might expected vivo when flows valve. The optimization thrombogenic performance MHVs could facilitated formulating robust numerical methodology predictive capabilities flow-induced activation. To achieve this objective, essential (i) quantify link realistic valve induced activation, (ii) integrate theoretical, numerical, approaches estimation associated specific geometry and/or working conditions implantable device. In work, comprehensive analysis Lagrangian systolic dynamics trajectories their histories bileaflet MHV presented. This study uses information extracted simulations performed resolve field model means experimentally validated fluid-structure interaction approach [3]. potency device mechanically induce activation/damage platelets evaluated using Lagrangian-based cumulative recently identified vitro activity measurements [4,5].Copyright © 2009 ASME