The role of structural parameters in DNA cyclization.
作者： Ludmil B. Alexandrov , Alan R. Bishop , Kim Ø. Rasmussen , Boian S. Alexandrov
DOI: 10.1186/S12859-016-0897-9
关键词: Biology 、 DNA 、 Helix 、 Genetics 、 Biophysics 、 A-DNA 、 DNA microarray 、 Intrinsic curvature
摘要: Background The intrinsic bendability of DNA plays an important role with relevance for myriad essential cellular mechanisms. The flexibility a fragment can be experimentally and computationally examined by its propensity cyclization, quantified the Jacobson-Stockmayer J factor. In this study, we use well-established coarse-grained three-dimensional model seven distinct sets derived conformational parameters double helix to evaluate structural in calculating cyclization.
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