Cardiac Differentiation of Pluripotent Stem Cells

摘要: The ability of human pluripotent stem cells to differentiate towards the cardiac lineage has attracted significant interest, initially with a strong focus on regenerative medicine. ultimate goal repair heart by cardiomyocyte replacement has, however, proven challenging. Human differentiation been difficult control, but methods are improving, and process, certain extent, can be manipulated directed. cell-derived cardiomyocytes described date exhibit rather immature functional structural characteristics compared adult cardiomyocytes. Thus, future challenge will develop strategies reach higher degree maturation in vitro, isolate from heterogeneous pool differentiating cells, as well guide into desired subtype, that is, ventricular, atrial, pacemaker cells. In this paper, we discuss for generation their characteristics, highlight some applications