Lacidipine self-nanoemulsifying drug delivery system for the enhancement of oral bioavailability

摘要: Low bioavailability of Lacidipine (LD), an calcium channel blocker pose many challenges in the treatment hypertension. The objective this study was to formulate and characterize LD self-nanoemulsifying drug delivery systems (SNEDDS) improve oral drug. Formulations were evaluated for globule size, surface morphology, emulsification time, cloud point, content, vitro dissolution, ex vivo permeation, stability studies. Captex 810D, TPGS, Tween-60, Transcutol P PEG 400 selected based on solubility results. optimized SNEDDS readily gets nanoemulsified at 37 °C with droplet size 41 nm when mixed 200 times its water. Transmission electron microscope photographs confirmed spherical shape globules. In dissolution showed more than 80% release within 15 min. permeation from is 4.8- 9-fold higher compared pure absence presence verapamil respectively. no environmental effect physical nature content. Oral 2.5 marketed tablet. results suggest that, formulation can be used as a possible alternative traditional formulations bioavailability.