ALCOHOL WITHDRAWAL REACTIONS IN MICE: EFFECTS OF DRUGS THAT MODIFY NEUROTRANSMISSION

摘要: Mice were made physically dependent on ethanol by a three-day period of alcohol inhalation with small daily injections pyrazole to stabilize the blood levels. The severity withdrawal reaction was measured repeatedly scoring characteristic convulsions that could be elicited handling. effects neuropharmacological agents seizures observed. Drugs affect cholinergic systems (atropine, dihydro-β-erythroidine or physostigmine) had little no effect. Similarly, attempts modify serotonergic neurons p -chlorophenylalanine, tryptophan 5-hydroxytryptophan did not reaction. However, directed at γ-aminobutyric acid modified seizures; picrotoxin facilitated and aminooxyacetic suppressed convulsions. interfere catecholamine pathways (reserpine, α-methyltyrosine, phentolamine propranolol) aggravated seizures. Reserpine strongest most prolonged Apparently both tend suppress hyperexcitability state.