Prostate-specific antigen as a pretherapy prognostic factor in patients treated with radiation therapy for clinically localized prostate cancer.

作者: T M Pisansky , S S Cha , J D Earle , E D Durr , T F Kozelsky

DOI: 10.1200/JCO.1993.11.11.2158

关键词: Radiation therapyDiseaseProstateProstate cancerAntigenProstate-specific antigenPathologyAdenocarcinomaInternal medicineMedicineOncologyStage (cooking)

摘要: PURPOSEThis study was conducted to determine the value of prostate-specific antigen (PSA) as a pretherapy prognostic factor for localized prostate cancer treated with primary irradiation (RT).PATIENTS AND METHODSBetween March 1987 and December 1990, 254 patients PSA determinations were clinical stage A2 C adenocarcinoma. In conjunction other factors, evaluated whether it had independent predictive disease outcome.RESULTSPretherapy highly directly correlated stage, tumor grade, acid phosphatase level. With median follow-up duration 24 months, 241 (95%) fully assessable outcome. these patients, grade sole factors relapse (ie, clinically determined and/or increasing level). The combination information defined groups distinctly different out...

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