Protective effect of Yerba mate (Ilex paraguariensis St. Hill.) against oxidative damage in vitro in rat brain synaptosomal/mitochondrial P2 fractions
作者： María Eduarda de Lima , Ana C. Colpo , Marisol Maya-López , Hemerson Rosa , Isaac Túnez
DOI: 10.1016/J.JFF.2017.05.026
关键词: Biology 、 In vitro 、 Neuroprotection 、 Glutathione 、 Chlorogenic acid 、 Biochemistry 、 Antioxidant 、 Lipid peroxidation 、 Yerba-mate 、 Reactive oxygen species
摘要: Abstract Yerba mate extracts are naturally enriched with several antioxidant compounds. Therefore, this natural product constitutes a fertile field of research directed to test its and therapeutic properties in the Central Nervous System. We tested ability yerba prevent chemically-induced reactive oxygen species (ROS) formation, lipid peroxidation, glutathione balance (GSH:GSSG) disruption mitochondrial dysfunction vitro rat brain synaptosomal/mitochondrial fractions, compared these effects those most abundant compound chlorogenic acid (CGA). prevented depletion dysfunction, were correlated ROS formation. CGA oxidative damage but less intense than extract. Our results suggest that protective exhibited by cannot be merely attributable main component CGA.
sci-hub.se 参考文章(30)
Daniel Santamaría, Velia Espinoza-González, Camilo Ríos, Abel Santamaría, Nω-nitro-L-arginine, a nitric oxide synthase inhibitor, antagonizes quinolinic acid-induced neurotoxicity and oxidative stress in rat striatal slices Neurochemical Research. ,vol. 24, pp. 843- 848 ,(1999) , 10.1023/A:1020949812581
Olusola Olalekan Elekofehinti, Jean Paul Kamdem, Daiane Francine Meinerz, Ige Joseph Kade, Isaac Gbadura Adanlawo, João Batista Teixeira Rocha, Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe 2+ and sodium nitroprusside in rat brain synaptosome P2 fraction Archives of Pharmacal Research. pp. 1- 7 ,(2015) , 10.1007/S12272-014-0536-9
A.L. Colín-González, A.L. Paz-Loyola, I. Serratos, B. Seminotti, C.A.J. Ribeiro, G. Leipnitz, D.O. Souza, M. Wajner, A. Santamaría, Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias Neuroscience. ,vol. 308, pp. 64- 74 ,(2015) , 10.1016/J.NEUROSCIENCE.2015.09.002
Hanaa Ali Hassan Mostafa Abd El-Aal, Lipid Peroxidation End-Products as a Key of Oxidative Stress: Effect of Antioxidant on Their Production and Transfer of Free Radicals InTech. ,(2012) , 10.5772/45944
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
R. Filip, P. López, G. Giberti, J. Coussio, G. Ferraro, Phenolic compounds in seven South American Ilex species Fitoterapia. ,vol. 72, pp. 774- 778 ,(2001) , 10.1016/S0367-326X(01)00331-8
Kyungjin Lee, Jeong-Sook Lee, Hyeung-Jin Jang, Sung-Moo Kim, Mun Seog Chang, Si Hyung Park, Kwan Su Kim, Jinhyun Bae, Jae-Woo Park, Bumjun Lee, Ho-Young Choi, Chang-Hyun Jeong, Youngmin Bu, None, Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia European Journal of Pharmacology. ,vol. 689, pp. 89- 95 ,(2012) , 10.1016/J.EJPHAR.2012.05.028
N. Bracesco, A.G. Sanchez, V. Contreras, T. Menini, A. Gugliucci, Recent advances on Ilex paraguariensis research: minireview. Journal of Ethnopharmacology. ,vol. 136, pp. 378- 384 ,(2011) , 10.1016/J.JEP.2010.06.032
J. Han, Y. Miyamae, H. Shigemori, H. Isoda, Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. Neuroscience. ,vol. 169, pp. 1039- 1045 ,(2010) , 10.1016/J.NEUROSCIENCE.2010.05.049
Barry Halliwell, John M.C. Gutteridge, Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Letters. ,vol. 307, pp. 108- 112 ,(1992) , 10.1016/0014-5793(92)80911-Y