Sulfur mustard lowers nicotinamide adenine dinucleotide concentrations in human skin grafted to athymic nude mice
作者： C GROSS
DOI: 10.1016/0041-008X(85)90123-1
关键词: Human skin 、 NAD+ kinase 、 Chemistry 、 Nicotinamide adenine dinucleotide 、 Biochemistry 、 Internal medicine 、 Endocrinology 、 Sulfur mustard
摘要: Human skin grafted to athymic nude mice shows a decrease in nicotinamide adenine dinucleotide (NAD+) concentrations when exposed sulfur mustard (HD). The lowering of NAD+ is dependent on both dose HD and time after exposure. When applied at 127 μg/cm2, the begins immediately exposure, approaches minimal values by 4 hr. returned normal within 18 With higher HD, fall precipitously hr, reach minimum value seem remain this depressed for least 72 loss appears precede be proportional tissue injury. Pretreatment with 3-aminobenzamide, specific inhibitor poly(ADP-ribose) polymerase, seems lessen effect HD. At human grafts from pretreated 3-aminobenzamide show significant protection levels
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