Reaction of indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium: Synthesis of ellipticine
作者： Yasuyoshi Miki , Yoshitaka Tada , Norihide Yanase , Hiroko Hachiken , Ko-ichi Matsushita
DOI: 10.1016/0040-4039(96)01768-6
关键词: Product (mathematics) 、 Yield (chemistry) 、 Ellipticine 、 Indole test 、 Chemistry 、 Medicinal chemistry
摘要: Abstract N -Benzylindole-2,3-dicarboxylic anhydride ( 1 ) was reacted with (3-bromo-4-pyridyl)triisopropoxytitanium to give 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid 2 as the sole product in high yield, which could be converted ellipticine six steps.
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