Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof
作者： Pär Gellerfors , Lars Lannfelt
DOI:
关键词: Biochemistry 、 In vivo 、 Chemistry 、 Peptide 、 Vascular dementia 、 Antibody 、 In vitro 、 Antigen 、 Amyloid beta
摘要: The invention pertains to the development of antibodies that specifically bind amyloid beta protein (Abeta) in its protofibril conformation. also comprises methods using anti-Abeta diagnose or treat Alzheimer's disease, Down's syndrome Lewybody dementia, vascular and other neurodegenerative disorders. Furthermore, use screen identify substances will modulate activity formation vitro vivo. for synthesising pure Abeta antigens as well a method stabilising protofibrils protofibrils.
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