Relationship between blood levels of heavy metals and lung function based on the Korean National Health and Nutrition Examination Survey IV-V.
作者： Ji Ye Jung , Ah Young Leem , Se Kyu Kim , Joon Chang , Young Ae Kang
DOI: 10.2147/COPD.S86182
关键词: Vital capacity 、 Spirometry 、 FEV1/FVC ratio 、 Medicine 、 Odds ratio 、 Physiology 、 Cadmium 、 National Health and Nutrition Examination Survey 、 Body mass index 、 Quartile 、 Surgery
摘要: Heavy metal exposure may contribute to inflammation in the lungs via increased oxidative stress, resulting tissue destruction and obstructive lung function (OLF). In this study, we evaluated relationship between lead cadmium levels blood, Korean population.Pooled cross-sectional data from 5,972 subjects who participated National Health Nutrition Examination Survey 2008-2012 were used for study. OLF was defined as forced expiratory volume 1 second/forced vital capacity (FEV1/FVC) <0.7. Graphite-furnace atomic absorption spectrometry measure of blood.Adjusted means age, sex, body mass index, smoking status blood with age higher men current smokers. The FEV1/FVC ratio lower highest quartile group (78.4% vs 79.0%; P=0.025) (78.3% 79.2%; P<0.001) concentrations, compared those lowest groups. Multiple linear regression demonstrated an inverse concentrations (estimated -0.002; P=0.007) -0.005; P=0.001). Of subjects, 674 (11.3%) classified into group. Among smokers, risk concentration than (odds 1.94; 95% confidence interval 1.06-3.57).We a significant association population. elevated increasing among
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