Treatment of tauopathies

摘要: The invention is directed to methods of treatment Alzheimer's disease and other tauopathies, via the administration antibodies having specificity abnormal forms tau protein, showing no binding and/or reactivity a normal protein being administered under conditions in amounts effective prevent or treat tauopathies. In certain embodiments, are selective for soluble truncated at (i) its C-terminus after glutamic acid residue Glu391, (ii) aspartic Asp421, (iii) N-terminus Asp13, (iv) combination (i)-(iii). Further aspects an immunogen comprising tau, preferably tau.