A Genetic Circuit Compiler: Generating Combinatorial Genetic Circuits with Web Semantics and Inference

作者: William Waites , Göksel Mısırlı , Matteo Cavaliere , Vincent Danos , Anil Wipat

DOI: 10.1021/ACSSYNBIO.8B00201

关键词: Synthetic biologyComputer scienceCode (cryptography)InferenceProgramming languageSemantic WebCompilerSemantics (computer science)Structure (mathematical logic)Electronic circuit

摘要: A central strategy of synthetic biology is to understand the basic processes living creatures through engineering organisms using same building blocks. Biological machines described in terms parts can be studied by computer simulation any several languages or robotically assembled vitro. In this paper we present a language, Genetic Circuit Description Language (GCDL) and compiler, Compiler (GCC). This language describes genetic circuits at level granularity appropriate both for automated assembly laboratory deriving code. The GCDL follows Semantic Web practice, compiler makes novel use logical inference facilities that are therefore available. We structure as study tool generating κ-language simulations from semantic descriptions circuits.

参考文章(28)
Calin C Guet, Michael B Elowitz, Weihong Hsing, Stanislas Leibler, Combinatorial Synthesis of Genetic Networks Science. ,vol. 296, pp. 1466- 1470 ,(2002) , 10.1126/SCIENCE.1067407
Michael B. Elowitz, Stanislas Leibler, A synthetic oscillatory network of transcriptional regulators Nature. ,vol. 403, pp. 335- 338 ,(2000) , 10.1038/35002125
Michael J Smanski, Swapnil Bhatia, Dehua Zhao, YongJin Park, Lauren B A Woodruff, Georgia Giannoukos, Dawn Ciulla, Michele Busby, Johnathan Calderon, Robert Nicol, D Benjamin Gordon, Douglas Densmore, Christopher A Voigt, Functional optimization of gene clusters by combinatorial design and assembly Nature Biotechnology. ,vol. 32, pp. 1241- 1249 ,(2014) , 10.1038/NBT.3063
Hugo G Menzella, Ralph Reid, John R Carney, Sunil S Chandran, Sarah J Reisinger, Kedar G Patel, David A Hopwood, Daniel V Santi, Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes Nature Biotechnology. ,vol. 23, pp. 1171- 1176 ,(2005) , 10.1038/NBT1128
C. J. Paddon, P. J. Westfall, D. J. Pitera, K. Benjamin, K. Fisher, D. McPhee, M. D. Leavell, A. Tai, A. Main, D. Eng, D. R. Polichuk, K. H. Teoh, D. W. Reed, T. Treynor, J. Lenihan, H. Jiang, M. Fleck, S. Bajad, G. Dang, D. Dengrove, D. Diola, G. Dorin, K. W. Ellens, S. Fickes, J. Galazzo, S. P. Gaucher, T. Geistlinger, R. Henry, M. Hepp, T. Horning, T. Iqbal, L. Kizer, B. Lieu, D. Melis, N. Moss, R. Regentin, S. Secrest, H. Tsuruta, R. Vazquez, L. F. Westblade, L. Xu, M. Yu, Y. Zhang, L. Zhao, J. Lievense, P. S. Covello, J. D. Keasling, K. K. Reiling, N. S. Renninger, J. D. Newman, High-level semi-synthetic production of the potent antimalarial artemisinin Nature. ,vol. 496, pp. 528- 532 ,(2013) , 10.1038/NATURE12051
Maxwell L. Neal, Michael T. Cooling, Lucian P. Smith, Christopher T. Thompson, Herbert M. Sauro, Brian E. Carlson, Daniel L. Cook, John H. Gennari, A Reappraisal of How to Build Modular, Reusable Models of Biological Systems PLoS Computational Biology. ,vol. 10, pp. e1003849- ,(2014) , 10.1371/JOURNAL.PCBI.1003849
Kai Yu, Chengcheng Liu, Byung-Gee Kim, Dong-Yup Lee, Synthetic fusion protein design and applications. Biotechnology Advances. ,vol. 33, pp. 155- 164 ,(2015) , 10.1016/J.BIOTECHADV.2014.11.005
William S. Hlavacek, James R. Faeder, Michael L. Blinov, Alan S. Perelson, Byron Goldstein, The complexity of complexes in signal transduction. Biotechnology and Bioengineering. ,vol. 84, pp. 783- 794 ,(2003) , 10.1002/BIT.10842
Michal Galdzicki, Kevin P Clancy, Ernst Oberortner, Matthew Pocock, Jacqueline Y Quinn, Cesar A Rodriguez, Nicholas Roehner, Mandy L Wilson, Laura Adam, J Christopher Anderson, Bryan A Bartley, Jacob Beal, Deepak Chandran, Joanna Chen, Douglas Densmore, Drew Endy, Raik Grünberg, Jennifer Hallinan, Nathan J Hillson, Jeffrey D Johnson, Allan Kuchinsky, Matthew Lux, Goksel Misirli, Jean Peccoud, Hector A Plahar, Evren Sirin, Guy-Bart Stan, Alan Villalobos, Anil Wipat, John H Gennari, Chris J Myers, Herbert M Sauro, The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology Nature Biotechnology. ,vol. 32, pp. 545- 550 ,(2014) , 10.1038/NBT.2891
Nicholas Roehner, Zhen Zhang, Tramy Nguyen, Chris J. Myers, Generating Systems Biology Markup Language Models from the Synthetic Biology Open Language. ACS Synthetic Biology. ,vol. 4, pp. 873- 879 ,(2015) , 10.1021/SB5003289