Central Nervous System and Limb Anomalies in Case Reports of First-Trimester Statin Exposure

摘要: To the Editor: The cholesterol-lowering statin drugs are contraindicated in pregnancy1; therefore, few data exist regarding their safety human gestation. We reviewed 178 cases of first-trimester exposure reported to Food and Drug Administration (FDA) from 1987 through 2001 for patterns suggesting possible drug-related effects on embryogenesis. After exclusion involving elective or spontaneous abortions (46 42 cases, respectively), pregnancy loss due maternal illness (15), fetal genetic disorders (3), transient neonatal (5), follow-up 52 were considered evaluable (Table 1). Among these there 20 reports . . .