HIV-specific cytotoxic T lymphocytes in seropositive individuals.

摘要: Virus-specific cytotoxic T lymphocytes (CTL) which kill virus-infected cells are thought to be a major host defence against viral infections. Here we report the existence of human immunodeficiency virus (HIV)-specific CTL in persons infected with this virus, aetiological agent AIDS (acquired syndrome). Recombinant HIV-vaccinia viruses were used express HIV antigens B-cell lines established from subjects seropositive for and seronegative controls. Circulating capable killing env-expressing autologous B detected eight subjects; addition, at least three demonstrated gag-specific responses. No HIV-specific cytotoxicity was observed subjects. Selective inhibition env-specific by CD3-specific monoclonal antibody indicates that effectors cells. This demonstration T-cell immune response individuals should prove useful investigating immunopathogenesis infection further evaluating vaccine strategies.