Ion Channel Localization in Axons

摘要: Axonal voltage-gated ion channels mediate diverse electrical events, the most fundamental being propagation of anterograde action potentials from soma to presynaptic terminal. This and other axonal events depend on appropriate expression, localization, function a repertoire that together allow for efficient transmission signals. article discusses found axons complex molecular interactions generate maintain their densities activities at precise sites in axons. Disruption channel localization by disease, injury, or genetic defect leads conduction failures neuropathological symptoms that, depending type neuron affected, can include pain, blindness, ataxia, epilepsy.