The therapeutic potential of human olfactory-derived stem cells.

摘要: Stem cells from fetal and adult central nervous system have been isolated characterized, providing populations for potential replacement therapy traumatic injury repair neurodegenerative diseases. The regenerative capacity of the olfactory has attracted scientific interest. Studies focusing on animal human bulb ensheathing (OECs) heightened expectations that OECs can enhance axonal regeneration demyelinating Harvest requires highly invasive surgery, which is a major obstacle. In contrast, epithelium (OE) unique readily accessible its location in nasal cavity, allowing harvest without lasting damage to donor. Adult OE contains progenitors responsible normal life-long continuous neurons supporting cells. Culture techniques established generate mitotically active neural form neurospheres (Roisen et al., 2001; Winstead 2005). application this technology includes autologous transplantation where minimal donor material be isolated, expanded ex vivo, lineage restricted desired phenotype prior to/or after re-implantation. Furthermore, these strategies circumvent ethical issues arise with embryonic or tissues. long term goal develop procedures through victim spinal cord condition would serve as source his/her own grafts, avoiding need immunosuppression controversy. addition, provide pharmacological and/or diagnostic evaluation.