Changes on auditory physiology in response to the inactivation of amygdala nuclei in high anxiety rats expressing learned fear.

摘要: Abstract The inferior colliculus (IC) is primarily involved in the processing of acoustic stimuli, including those emitted by prey and predators. role central nucleus IC (CIC) fear anxiety has been suggested based on electrophysiological, behavioral immunohistochemical studies. reactivity high-anxiety rats (HA) to diverse challenges different from low-anxiety ones (LA). In humans laboratory animals, pathological often accompanied heightened vigilance alertness, hyperactivity amygdala (AM), increased amplitude auditory evoked potentials (AEP) IC. This study aims evaluate influence inactivation (CEA) basolateral (BLA) nuclei amygdala, after local infusions full GABA A agonist muscimol (1 nmol/0.2 μl), AEP elicited CIC tested under a learned state. Our results showed that both BLA CEA change expression conditioned fear, paradigm using context as stimulus (CS). These changes are correlated innate levels animals. It supposed this shortcoming addition imbalance between regulatory top-down bottom-up processes control anxiety.