A versatile polyion complex can intelligently respond to a tumor microenvironment to eliminate tumor stem cells for enhanced lung cancer targeted therapy
作者： Jiulong Zhang , Xiufeng Zhao , Chunrong Yang , Ziyuan Huang , Menghao Shi
DOI: 10.1039/C9BM00812H
关键词: Tumor microenvironment 、 Chemistry 、 Stem cell 、 Tyrosine kinase 、 PTK7 、 A549 cell 、 Cancer research 、 Cancer cell 、 Targeted therapy 、 Signal transduction
摘要: Poor prognosis in lung cancer has been proved to be associated with the presence of stem cells (LCSCs). Similar bulk and always existing interior a solid tumor, there are also insurmountable barriers for elimination CSCs. To overcome these drawbacks, versatile polyion complex was rationally designed, which can respond tumor microenvironment exhibits size-variable property, allows it possess remarkable penetration capability accumulate around LCSCs. Protein tyrosine kinase 7 (PTK7) antibody mediated active targetability facilitate cellular uptake triphenylphosphine-docetaxel (TD) microRNA-31(miR-31) breakage disulfide bond enhance intracellular drug release. TD possesses favorable apoptosis-inducing effect via mitochondria pathway, while miR-31 could significantly regulate MET-PI3K-Akt signaling pathway exert eliminate APSP/HA might support new insights into LCSC eradiation management.
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