Association between polymorphism of MMP-1 promoter and the susceptibility to anterior disc displacement and temporomandibular joint osteoarthritis
作者： Shufang Luo , Mohong Deng , Xing Long , Jian Li , Liqin Xu
DOI: 10.1016/J.ARCHORALBIO.2015.08.001
关键词: Genotype frequency 、 Medicine 、 Case-control study 、 Single-nucleotide polymorphism 、 Osteoarthritis 、 Hardy–Weinberg principle 、 Gastroenterology 、 Genotype 、 Temporomandibular joint 、 Pathology 、 Internal medicine 、 Allele frequency
摘要: Abstract Objective To investigate the correlation of polymorphism MMP-1 promoter (−1607 1G/2G) with susceptibility to anterior disc displacement (ADD) and temporomandibular joint osteoarthritis (TMJ OA). Methods A total 185 healthy individuals (group A), 141 unilateral ADDWR patients B), 321 ADDWOR C) were included in investigation. Group C 115 without TMJ OA (named group C-1) 206 C-2). The genotyping this single nucleotide was evaluated by high resolution melting assay. Pairwise comparison between distributions genotypes alleles these groups conducted a multivariate logistic regression model adjusted on basis possible covariates. Results significant difference 2G2G genotype frequency found among different three sets comparisons ( P C-A C1-B = 0.049; C2-B = 0.018). carriers or considerably higher than that other (OR = 2.455; OR = 1.849; = 1.912). 1G2G also observed two = 0.041). = 2.641; = 1.896). Conclusion −1607 1G/2G may be related OA.
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