Centromeric heterochromatin polymorphism in the house mouse. Evidence from inbred strains and natural populations.
作者： J. Forejt
DOI: 10.1007/BF00483378
关键词: Chromosome 、 Loss of heterozygosity 、 Heterochromatin 、 Chromosomal translocation 、 Centromere 、 Inbred strain 、 Genetics 、 Molecular biology 、 Biology 、 House mouse 、 Karyotype
摘要: Polymorphism of Giemsa-specific centromeric heterochromatin (C.H.) has been described in the laboratory and wild mice. All examined mice inbred mouse strains display some chromosomes with considerably reduced or enlarged C.H. regions. The quantity could be an inherent property a chromosome as inferred from (a) finding identical pattern within strains, (b) that two genetically related C3H CBA, separated each other for more than 150 generations, possess same pairs tiny marker These were identified No. 1 (l.g. XIII) 14 (l.g.III) by means T(14;15)6Ca translocation, C- G-band analysis. neutrality polymorphism murine genome is “heterozygosity” variants found all studied possible relationship to centromere interference phenomenon hypothesized.
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