Liquid chromatographic determination of the enantiomers of ibuprofen in plasma using a chiral AGP column.
作者： Karl-Johan Pettersson , Anette Olsson
DOI: 10.1016/0378-4347(91)80050-M
关键词: Plasma 、 Chromatography 、 Ibuprofen 、 Chemistry 、 Biological fluid 、 Chiral stationary phase 、 Analytical chemistry 、 High-performance liquid chromatography 、 Enantiomer 、 Reversed-phase chromatography
摘要: A reversed-phase high-performance liquid chromatographic method has been developed for the determination of R- and S-enantiomers ibuprofen. The enantiomers internal standard 4-pentylphenylacetic acid are extracted from plasma, separated quantified on a Chiral-AGP column using ultraviolet detection. simplicity, sensitivity precision makes it convenient use in pharmacokinetic studies.
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