Purified Gymnemic Acids from Gymnema inodorum Tea Inhibit 3T3-L1 Cell Differentiation into Adipocytes.

摘要: Gymnema inodorum (GI) is an indigenous medicinal plant and functional food in Thailand that has recently helped to reduce plasma glucose levels healthy humans. It renowned for the properties of gymnemic acid its ability suppress absorption. However, effects acids on adipogenesis contribute accumulation adipose tissues associated with obesity remain unknown. The present study aimed determine derived from GI tea adipogenesis. We purified identified GiA-7 stephanosides C B inhibited adipocyte differentiation 3T3-L1 cells. These compounds also suppressed expression peroxisome proliferator-activated receptor gamma (Pparγ)-dependent genes, indicating they inhibit lipid early stage preadipocyte differentiation. Only induced uncoupling protein 1 (Ucp1) pparγ coactivator alpha (Pgc1α), suggesting induces mitochondrial activity beige-like adipocytes. This first finding inodorum. Our results suggested could help prevent obesity.