The degeneration of upper and lower motor neuron from the perspective of clinical neurological examination and MRI-electromyography manifold detection in amyotrophic lateral sclerosis.

摘要: OBJECTIVE The aim of this study was to explore the upper motor neurons (UMN) and lower (LMN) degeneration in amyotrophic lateral sclerosis (ALS) from perspective clinical neurological examination MRI-electromyography manifold detection, respectively. METHODS data, cortical thickness corresponding areas different body regions MRI electromyography data were collected 108 classical ALS patients. RESULTS kappa value UMN LMN involvement signs bulbar region (0.31) higher than that left limb (-0.13), right (-0.27), (-0.05) (-0.08). positive damage group thinner negative head-face area (P < 0.05; Cohen's d = 0.84); however, showed no significant differences head-face, bilateral tongue-larynx, upper-limb, trunk lower-limb between LMN-damage-positive LMN-damage-negative groups. CONCLUSION neuron could be independent through levels. degenerative process not only confined levels but can also expand white matter fiber tracts. Thus, might system's three-dimensional anatomy.