Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti‐tuberculosis vaccine and drug design
作者： Asma Ahmed , Arghya Das , Sangita Mukhopadhyay
DOI: 10.1002/IUB.1387
关键词: Immunology 、 Biology 、 Pathogenicity 、 Drug 、 Mycobacterium tuberculosis 、 Anti tuberculosis 、 Tuberculosis 、 Virulence 、 Genome
摘要: The Mycobacterium tuberculosis genome was sequenced more than 15 years ago. It revealed a lot of interesting information, one which that 10% the total coding capacity M. is dedicated to PE/PPE family. There gradual expansion these proteins from nonpathogenic pathogenic mycobacteria, and there increasing evidence play important roles in mycobacterial pathogenesis. In this review, we discuss proteins, their close functional association with ESX clusters, immunomodulatory functions, virulence. addition, have attempted review compile information available literature detailing expression patterns family members different species also during infection. Our attempt has been provide succinct overview © 2015 IUBMB Life, 67(6):414–427,
sci-hub.se 参考文章(147)
Nicolaas C Gey van Pittius, Samantha L Sampson, Hyeyoung Lee, Yeun Kim, Paul D van Helden, Robin M Warren, Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions BMC Evolutionary Biology. ,vol. 6, pp. 95- 95 ,(2006) , 10.1186/1471-2148-6-95
Kristi M. Guinn, Mark J. Hickey, Sanjeev K. Mathur, Kelly L. Zakel, Jeff E. Grotzke, David M. Lewinsohn, Sherilyn Smith, David R. Sherman, Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis Molecular Microbiology. ,vol. 51, pp. 359- 370 ,(2004) , 10.1046/J.1365-2958.2003.03844.X
Raffaella Iantomasi, Michela Sali, Alessandro Cascioferro, Ivana Palucci, Antonella Zumbo, Silvia Soldini, Stefano Rocca, Emanuela Greco, Giuseppe Maulucci, Marco De Spirito, Maurizio Fraziano, Giovanni Fadda, Riccardo Manganelli, Giovanni Delogu, PE_PGRS30 is required for the full virulence of Mycobacterium tuberculosis Cellular Microbiology. ,vol. 14, pp. 356- 367 ,(2012) , 10.1111/J.1462-5822.2011.01721.X
Yongjun Li, Elizabeth Miltner, Martin Wu, Mary Petrofsky, Luiz E. Bermudez, A Mycobacterium avium PPE gene is associated with the ability of the bacterium to grow in macrophages and virulence in mice. Cellular Microbiology. ,vol. 7, pp. 539- 548 ,(2004) , 10.1111/J.1462-5822.2004.00484.X
Sylvie Bertholet, Gregory C. Ireton, Maria Kahn, Jeffrey Guderian, Raodoh Mohamath, Nicole Stride, Elsa M. Laughlin, Susan L. Baldwin, Thomas S. Vedvick, Rhea N. Coler, Steven G. Reed, Identification of Human T Cell Antigens for the Development of Vaccines against Mycobacterium tuberculosis Journal of Immunology. ,vol. 181, pp. 7948- 7957 ,(2008) , 10.4049/JIMMUNOL.181.11.7948
Khalid Hussain Bhat, Arghya Das, Aparna Srikantam, Sangita Mukhopadhyay, None, PPE2 protein ofMycobacterium tuberculosismay inhibit nitric oxide in activated macrophages Annals of the New York Academy of Sciences. ,vol. 1283, pp. 97- 101 ,(2013) , 10.1111/NYAS.12070
Shiny Nair, Akhilesh Datt Pandey, Sangita Mukhopadhyay, The PPE18 Protein of Mycobacterium tuberculosis Inhibits NF-κB/rel-Mediated Proinflammatory Cytokine Production by Upregulating and Phosphorylating Suppressor of Cytokine Signaling 3 Protein Journal of Immunology. ,vol. 186, pp. 5413- 5424 ,(2011) , 10.4049/JIMMUNOL.1000773
Paul J. Maglione, Jiayong Xu, John Chan, B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis Journal of Immunology. ,vol. 178, pp. 7222- 7234 ,(2007) , 10.4049/JIMMUNOL.178.11.7222
Elena Giacomini, Elisabetta Iona, Lucietta Ferroni, Minja Miettinen, Lanfranco Fattorini, Graziella Orefici, Ilkka Julkunen, Eliana M. Coccia, Infection of Human Macrophages and Dendritic Cells withMycobacterium tuberculosisInduces a Differential Cytokine Gene Expression That Modulates T Cell Response The Journal of Immunology. ,vol. 166, pp. 7033- 7041 ,(2001) , 10.4049/JIMMUNOL.166.12.7033
Emily P Thi, Chris Joon Ho Hong, Gaganjit Sanghera, Neil E Reiner, None, Identification of the Mycobacterium tuberculosis protein PE‐PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression Cellular Microbiology. ,vol. 15, pp. 795- 808 ,(2013) , 10.1111/CMI.12073