Digitalis sensitivity of Na+,K+-ATPase, myocytes and the heart
作者： Tai Akera , Yuk-Chow Ng
DOI: 10.1016/0024-3205(91)90402-W
关键词: Myocyte 、 Sodium 、 ATPase 、 Glycoside 、 Diaphragm pump 、 Endocrinology 、 Digitalis Toxicity 、 Internal medicine 、 Na+/K+-ATPase 、 Digitalis 、 Chemistry
摘要: Abstract Cardiac Na + ,K -ATPase, the receptor molecule for digitalis glycosides, have isoforms with different intrinsic affinities glycosides. Expressionof these are under developmental and hormonal regulation. Switching in to those lower affinity may decrease sensitivity of heart. In addition cardiac -ATPase glycoside, increases rate influx decreases extracellular K concentrations increase glycoside heart also reduces margin safety by reducing reserve capacity sodium pump. Reserve pump is reduced pathological conditions or aging, resulting glycoside. Events that follow inhibition effect toxicity. These hypercalcemia magnesium depletion. It now feasible predict heart, not empirically but based on understanding mechanisms responsible positive inotropic toxic actions
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