TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6
作者： Dominika Nackiewicz , Meixia Dan , Wei He , Rosa Kim , Anisa Salmi
DOI: 10.1007/S00125-014-3249-1
关键词: TLR4 、 Secretion 、 Beta cell 、 Inflammation 、 Chemistry 、 Islet 、 TLR2 、 PDX1 、 Endocrinology 、 IL1A 、 Internal medicine 、 Endocrinology, Diabetes and Metabolism
摘要: … of the assay, as published previously for rat islets [6]. However, IL-6 secretion did not differ in … in the absence or presence of Pam2CSK4 or LPS and qPCR (c–i) or cytokine secretion (j, l) …
springer.com
sci-hub.se 参考文章(49)
Li Wen, Jian Peng, Zhenjun Li, F. Susan Wong, The Effect of Innate Immunity on Autoimmune Diabetes and the Expression of Toll-Like Receptors on Pancreatic Islets Journal of Immunology. ,vol. 172, pp. 3173- 3180 ,(2004) , 10.4049/JIMMUNOL.172.5.3173
Edwin J.P. van Asseldonk, Rinke Stienstra, Tim B. Koenen, Lambertus J.H. van Tits, Leo A.B. Joosten, Cees J. Tack, Mihai G. Netea, The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation. Obesity. ,vol. 18, pp. 2234- 2236 ,(2010) , 10.1038/OBY.2010.55
Francis Kim, Matilda Pham, Ian Luttrell, Douglas D. Bannerman, Joan Tupper, Joshua Thaler, Thomas R. Hawn, Elaine W. Raines, Michael W. Schwartz, Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity Circulation Research. ,vol. 100, pp. 1589- 1596 ,(2007) , 10.1161/CIRCRESAHA.106.142851
Deanna L. Gibson, Marinieve Montero, Mark J. Ropeleski, Kirk S.B. Bergstrom, Caixia Ma, Sanjoy Ghosh, Helen Merkens, Jingtian Huang, Lisa E. Månsson, Ho Pan Sham, Kelly M. McNagny, Bruce A. Vallance, Interleukin-11 Reduces TLR4-Induced Colitis in TLR2-Deficient Mice and Restores Intestinal STAT3 Signaling Gastroenterology. ,vol. 139, pp. 1277- 1288 ,(2010) , 10.1053/J.GASTRO.2010.06.057
M. Igoillo-Esteve, L. Marselli, D. A. Cunha, L. Ladrière, F. Ortis, F. A. Grieco, F. Dotta, G. C. Weir, P. Marchetti, D. L. Eizirik, M. Cnop, Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes Diabetologia. ,vol. 53, pp. 1395- 1405 ,(2010) , 10.1007/S00125-010-1707-Y
Marianne Böni-Schnetzler, Simone Boller, Sarah Debray, Karim Bouzakri, Daniel T. Meier, Richard Prazak, Julie Kerr-Conte, Francois Pattou, Jan A. Ehses, Frans C. Schuit, Marc Y. Donath, Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology. ,vol. 150, pp. 5218- 5229 ,(2009) , 10.1210/EN.2009-0543
J. C. Pickup, M. A. Crook, Is Type II diabetes mellitus a disease of the innate immune system Diabetologia. ,vol. 41, pp. 1241- 1248 ,(1998) , 10.1007/S001250051058
L.-H. Kuo, P.-J. Tsai, M.-J. Jiang, Y.-L. Chuang, L. Yu, K.-T. A. Lai, Y.-S. Tsai, Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse. Diabetologia. ,vol. 54, pp. 168- 179 ,(2011) , 10.1007/S00125-010-1931-5
Ryan W. Himes, C. Wayne Smith, Tlr2 is critical for diet-induced metabolic syndrome in a murine model The FASEB Journal. ,vol. 24, pp. 731- 739 ,(2010) , 10.1096/FJ.09-141929
Claus M. Larsen, Mirjam Faulenbach, Allan Vaag, Aage Vølund, Jan A. Ehses, Burkhardt Seifert, Thomas Mandrup-Poulsen, Marc Y. Donath, Interleukin-1-receptor antagonist in type 2 diabetes mellitus. The New England Journal of Medicine. ,vol. 356, pp. 1517- 1526 ,(2007) , 10.1056/NEJMOA065213