Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer's disease rats.

摘要: In the brain, REST (Repressor Element-1 Silencing Transcription factor) is a key regulator of neuron cell-specific gene expression. Nuclear translocation neuronal has been shown to be neuroprotective in healthy ageing context. contrast, inability upregulate nuclear thought leave neurons vulnerable neurodegenerative stimuli, such as Alzheimer's disease (AD) pathology. Hippocampal and cortical are known particularly susceptible AD-associated neurodegeneration. However, expression not extensively characterised brain. Here, we examined spatiotemporal immunolocalisation brains wild-type Fischer-344 transgenic rats (TgF344-AD). increased from 6 months 18 age hippocampus, frontal cortex subiculum rats, but TgF344-AD rats. No changes were measured more posterior regions or thalamus. Interestingly, levels presynaptic marker synaptophysin, target REST, lower CA1 hippocampal 18-month compared wild-types, suggesting that elevated may protect against synapse loss High did not, however, axonal nor astroglial reactivity hippocampus. Taken together, our data confirm context-, age- brain region-specific. Moreover, structures involved learning memory display