γ‐Vinyl GABA: A double‐blind placebo‐controlled trial in partial epilepsy
作者： Lennart Gram , Peter Klosterskov , Mogens Dam
关键词: γ vinyl gaba 、 Partial epilepsy 、 Anesthesia 、 Concomitant 、 GABAergic 、 Adverse effect 、 Medicine 、 Mechanism of action 、 Double blind 、 Placebo-controlled study
摘要: The antiepileptic effect of γ-vinyl γ-aminobutyric acid (GABA), an irreversible GABA-transaminase inhibitor, was investigated in add-on, placebo-controlled, double-blind, cross-over, fixed-dose trial. Twenty-one patients suffering from difficult to control complex partial seizures participated; 18 completed the Serum levels concomitant drugs were kept constant throughout Three (17%) reduction seizure frequency and 8 (44%) reduced by at least 50%. Two developed a modereat 1 patient marked increase during treatment with GABA. Except for 2 patients, who had discontinue trial becuase adverse effects GABA, participants unable discriminate between regimens regard side effefts GABA seems be promosing new drug, first one present convincing evidence GABAergic mechanism action.
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