When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells.
作者： Fuquan Chen , Jiaojiao Ji , Jian Shen , Xinyi Lu
DOI: 10.1155/2017/3250624
关键词: Dosage compensation 、 RNA splicing 、 Transcriptional regulation 、 Genome editing 、 Human genome 、 Genetics 、 Imprinting (psychology) 、 Induced pluripotent stem cell 、 Biology 、 Gene
摘要: Most of the human genome can be transcribed into RNAs, but only a minority these regions produce protein-coding mRNAs whereas remaining are noncoding RNAs. Long RNAs (lncRNAs) were known for their influential regulatory roles in multiple biological processes such as imprinting, dosage compensation, transcriptional regulation, and splicing. The physiological functions genes have been extensively characterized through editing pluripotent stem cells (PSCs) past 30 years; however, study lncRNAs with technologies came attentions recent years. Here, we summarize advancements dissecting PSCs highlight potential tools useful examining PSCs.
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