ANCA as a Predictor of Relapse: Useful in Patients with Renal Involvement But Not in Patients with Nonrenal Disease

摘要: The value of measuring ANCA during follow-up to predict a relapse is controversial. On the basis recently obtained pathophysiologic insights, we postulated that useful in patients with renal involvement but less valuable nonrenal disease. One hundred sixty-six consecutive ANCA-associated vasculitis, positive for either proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA, were included our study, followed at regular intervals, and tested PR3-ANCA MPO-ANCA. In this cohort, 104 had (72 PR3-ANCA, 32 MPO-ANCA) 62 disease (36 26 MPO-ANCA). During an average (±SD) 49±33 months 18±14 measurements, 89 rises 74 relapses recorded. correlated who presented (hazard ratio [HR], 11.09; 95% confidence interval [95% CI], 5.01 24.55), comparison, associated only weakly (HR, 2.79; CI, 1.30 5.98). conclusion, longitudinal measurements may be