Cumulative Dose Threshold for the Chemopreventive Effect of Aspirin Against Gastric Cancer.

摘要: Many studies have found evidence that aspirin has protective effects against certain cancers, but quantitative dose–response data been available only on a limited basis. This study aimed to confirm the relationship of usage and gastric cancer estimate cumulative dose threshold achieve in general population. A total 461,489 individuals population-based longitudinal cohort provided by National Health Insurance Services (NHIS) Republic Korea were observed from 2007 2012 identify incident cases. The pharmacy claims these 2002 2006 reviewed assess medication exposure using defined daily (DDD) system. Hazard ratios (HRs) use for estimated multivariate Cox Proportional regression. Sensitivity analyses, including propensity-score matching nested case–control design, performed evaluate variability caused design. 5674 cancers identified 2,965,500 person-years follow-up observation, giving an overall incidence rate 191.00 per 100,000 person-years. Compared non-users, those with ≥3 DDD-years showed statistically significant effect cancer; adjusted HR (95% confidence intervals) 0.79 (0.63–0.98) 0.63 (0.48–0.83) 3–4 4–5 DDD-years, respectively (P trend  3 DDD-years.