Production of Fatty Acid-derived valuable chemicals in synthetic microbes
作者： Ai-Qun Yu , Nina Kurniasih Pratomo Juwono , Susanna Su Jan Leong , Matthew Wook Chang
关键词: Mrna secondary structure 、 Metabolic engineering 、 Yeast 、 Biology 、 Fatty acid derivatives 、 Biochemistry 、 Gene Circuits 、 Fatty acid 、 Microorganism 、 Synthetic biology 、 Biotechnology
摘要: Fatty acid derivatives, such as hydroxy fatty acids, alcohols, methyl/ethyl esters, and alka(e)nes, have a wide range of industrial applications including plastics, lubricants, fuels. Currently, these chemicals are obtained mainly through chemical synthesis, which is complex costly, their availability from natural biological sources extremely limited. Metabolic engineering microorganisms has provided platform for effective production valuable biochemicals. Notably, synthetic biology-based metabolic strategies been extensively applied to refactor improved biochemical production. Here, we reviewed: (i) the current status microbes that produce acid-derived chemicals, (ii) recent progress biology approaches assist engineering, mRNA secondary structure sensor-regulator system, regulatable expression ultrasensitive input/output control computer science-based design gene circuits. Furthermore, key challenges were discussed. Finally, concluded provides useful economically viable in engineered microbes.
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