Sensation is painless
作者： Miriam B Goodman
DOI: 10.1016/J.TINS.2003.09.013
关键词: Sensation 、 Noxious stimulus 、 Fish <Actinopterygii> 、 Sensory system 、 Adequate stimulus 、 Feeling 、 Drosophila Protein 、 Psychology 、 Neuroscience 、 Drosophila larvae
摘要: Emily Dickinson declared: 'After great pain, a formal feeling comes'. This begins when sensory neurons are activated by noxious stimuli, such as stepping on tack. Recently, Seymour Benzer's group identified in Drosophila larvae that mediate aversive responses to heat and mechanical stimuli. Thresholds for behavioral nerve elevated mutations the painless gene, which encodes TRP ion channel protein. Painless thus joins an elite of TRPs implicated transduction insects, nematodes, mammals fish.
elsevier.com
sci-hub.se 参考文章(20)
Ardem Patapoutian, Andrea M. Peier, Gina M. Story, Veena Viswanath, ThermoTRP channels and beyond: mechanisms of temperature sensation Nature Reviews Neuroscience. ,vol. 4, pp. 529- 539 ,(2003) , 10.1038/NRN1141
Samuel Sidi, Rainer W Friedrich, Teresa Nicolson, NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science. ,vol. 301, pp. 96- 99 ,(2003) , 10.1126/SCIENCE.1084370
C. S. Sherrington, Qualitative difference of spinal reflex corresponding with qualitative difference of cutaneous stimulus The Journal of Physiology. ,vol. 30, pp. 39- 46 ,(1903) , 10.1113/JPHYSIOL.1903.SP000980
Richard G Walker, Aarron T Willingham, Charles S Zuker, A Drosophila Mechanosensory Transduction Channel Science. ,vol. 287, pp. 2229- 2234 ,(2000) , 10.1126/SCIENCE.287.5461.2229
Ulrike Gr�nert, Werner Gnatzy, K+ and Ca++ in the receptor lymph of arthropod cuticular mechanoreceptors. Journal of Comparative Physiology A-neuroethology Sensory Neural and Behavioral Physiology. ,vol. 161, pp. 329- 333 ,(1987) , 10.1007/BF00615253
D.P. Corey, A.J. Hudspeth, Response latency of vertebrate hair cells. Biophysical Journal. ,vol. 26, pp. 499- 506 ,(1979) , 10.1016/S0006-3495(79)85267-4
Veena Viswanath, Gina M. Story, Andrea M. Peier, Matt J. Petrus, Van M. Lee, Sun Wook Hwang, Ardem Patapoutian, Tim Jegla, Opposite thermosensor in fruitfly and mouse Nature. ,vol. 423, pp. 822- 823 ,(2003) , 10.1038/423822A
James O. Pickles, David P. Corey, Mechanoelectrical transduction by hair cells. Trends in Neurosciences. ,vol. 15, pp. 254- 259 ,(1992) , 10.1016/0166-2236(92)90066-H
Rolf Bodmer, Yuh Nung Jan, Morphological differentiation of the embryonic peripheral neurons in Drosophila Roux's archives of developmental biology : the official organ of the EDBO. ,vol. 196, pp. 69- 77 ,(1987) , 10.1007/BF00402027
Janghwan Kim, Yun Doo Chung, Dae-young Park, SooKyung Choi, Dong Wook Shin, Heun Soh, Hye Won Lee, Wonseok Son, Jeongbin Yim, Chul-Seung Park, Maurice J Kernan, Changsoo Kim, None, A TRPV family ion channel required for hearing in Drosophila Nature. ,vol. 424, pp. 81- 84 ,(2003) , 10.1038/NATURE01733