Neuropeptides, trophic factors, and other substances providing morphofunctional and metabolic protection in experimental models of diabetic retinopathy.

摘要: Vision is the most important sensory modality for many species, including humans. Damage to retina results in vision loss or even blindness. One of serious complications diabetes, a disease that has seen worldwide increase prevalence, diabetic retinopathy. This condition stems from consequences pathological metabolism and develops 75% patients with type 1 50% 2 diabetes. The development novel protective drugs essential. In this review we provide description conclude diabetes lead same We evaluate existing experimental models recent developments finding effective compounds against disorder. our opinion, best are long-term streptozotocin-induced Otsuka Long-Evans Tokushima Fatty spontaneously Torii rats, while promising substances topically administered somatostatin pigment epithelium-derived factor analogs, antivasculogenic substances, systemic antioxidants. Future drug should focus on these.