Six-Week, Double-Blind, Placebo-Controlled Study of Desipramine for Adult Attention Deficit Hyperactivity Disorder

摘要: Objective : Despite the increasing awareness of attention deficit hyperactivity disorder (ADHD) in adults, there are a limited number controlled pharmacologic studies this ; most trials have focused on psychostimulants. Because tricyclic antidepressant desipramine has been found to be effective treating ADHD pediatric groups, authors tested its efficacy adults with ADHD. Method The conducted randomized, 6-week, placebo-controlled, parallel-design study at target daily dose 200 mg 41 adult patients DSM-III-R They used standardized structured psychiatric instruments for diagnosis and, as dependent variables (outcome), separate assessments ADHD, depressive, and anxiety symptoms baseline each biweekly visit. Results There were highly significant differences reduction between receiving placeho. Within desipramine-treated group, clinically statistically week 6 end point 1) 12 14 2) decreases broad categories hyperactivity, impulsivity, inattentivenes. In contrast, placebo-treated showed no any A DHD assessed. According strict, predefined criteria response, 68% subjects placebo group considered positive responders. Response was independent dose, level impairment, gender, or lifetime comorbidity depressive disorders. Conclusions These results, similar findings children adolescents indicate that is treatment adults.