Production of C2–C4 diols from renewable bioresources: new metabolic pathways and metabolic engineering strategies

摘要: C2–C4 diols classically derived from fossil resource are very important bulk chemicals which have been used in a wide range of areas, including solvents, fuels, polymers, cosmetics, and pharmaceuticals. Production renewable resources has received significant interest consideration the reducing increasing environmental issues. While bioproduction certain like 1,3-propanediol commercialized recent years, biosynthesis many other diol isomers is highly challenging due to lack natural synthesis pathways. Recent advances synthetic biology enabled de novo design completely new pathways non-natural molecules feedstocks. In this study, we review diols, focusing on metabolic engineering strategies being developed. We also discuss challenges future trends toward development economically competitive processes for bio-based production.