Mechanisms of Vascular Impairment During Endotoxaemia with special Reference to the Role of the L-arginine Pathway.
作者： I. Fleming , B. L. Furman , G. A. Gray , M. O. Guc , G. Julou-Schaeffer
DOI: 10.1007/978-3-642-76511-7_16
关键词: Septic shock 、 Nitric oxide 、 Shock (circulatory) 、 Cardiac output 、 Lipopolysaccharide 、 Arginine 、 Internal medicine 、 Vascular resistance 、 Endocrinology 、 Medicine 、 Pathogenesis
摘要: The pattern of vascular tone seen in patients with the sepsis syndrome is generally, and certainly early stages, one reduced peripheral resistance, often a normal or elevated cardiac output (Siegel et al. 1971; Groeneveld 1986; Thijs 1988). This loss can be persistent (‘unrelenting hypotension’: 1987) major causes death these (Parker 1984). Circulating endotoxin (lipopolysaccharide; LPS) an important component human shock pathogenesis; indeed, administration small doses to volunteers results cardiovascular identical that septic (Parrillo, 1989).
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