Sequencing in Parkinson's disease. Abnormalities in programming and controlling movement.

摘要: Central programming deficits in Parkinson's disease (PD) were studied two reaction time (RT) experiments. In Experiment 1, PD patients and controls performed sequences of hand postures that varied length, the number different (repetitive vs heterogeneous), delay interval before movement. Before movement, group planned repetitive movements like whereas for heterogeneous RT increased less with sequence length group, implying preprogramming. The interresponse (IRT) data from showed had difficulty controlling movement such IRTs faster when longer, thus allowing more to schedule termination during course For sequences, made errors slower than changing postures, suggesting a deficit switching between responses. While decreased longer similarly both groups, IRT1 continued improve only but types specific first response. 2, subjects decisions about contained within sequence. patients' decision times improved problem identifying postures. results have implications levels motor dysfunction which emphasize influence complexity.