Serotonin via presynaptic 5-HT1 receptors attenuates synaptic transmission to immature rat motoneurons in vitro.
作者： S.Y. Wu , M.Y. Wang , N.J. Dun
DOI: 10.1016/0006-8993(91)90178-X
关键词: Afterhyperpolarization 、 Synaptic augmentation 、 Internal medicine 、 Inhibitory postsynaptic potential 、 Electrophysiology 、 Methysergide 、 Excitatory postsynaptic potential 、 Postsynaptic potential 、 Neuroscience 、 Neurotransmission 、 Endocrinology 、 Biology
摘要: Intracellular recordings were made from motoneurons in transverse spinal cord slices immature (12–20 day) rats and the effects of 5-HT on dorsal root evoked excitatory (EPSPs) inhibitory (IPSPs) postsynaptic potentials assessed. With or without causing a membrane polarization, (1–300 μM) depressed synaptic responses; IC50 was 6 μM. The effect potentiated by uptake inhibitor fluoxetine. 5-HT1A/1B agonists 5-CT 8-OH-DPAT 5-HT1B/1C agonist TFMPP reduced responses as well, with an 0.26, 2.2 0.28 μM, respectively. depressant not antagonized methysergide (0.1–1 μM), ketanserin (1–5 MDL 72222 (1–10 μM). Methysergide alone diminished some motoneurons. Spiperone partially fully 8-OH-DPAT, but ineffective against TFMPP. 5-HT-induced depression accompanied concomitant reduction glutamate-induced depolarization; latter enhanced after repeated exposure to Finally, afterhyperpolarization following single spike train spikes. results indicate that inhibits via presynaptic 5-HT1 receptors, activation which reduces liberation transmitters respective nerve endings.
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sci-hub.se 参考文章(49)
Z. G. Jiang, N. J. Dun, Actions of Acetylcholine on Spinal Motoneurons Springer, Boston, MA. pp. 283- 293 ,(1987) , 10.1007/978-1-4684-5266-2_23
Anders BjÖRklund, Bengt Falck, Ulf Stenevi, Microspectrofluorimetric Characterization of Monoamines in the Central Nervous System: Evidence for a New Neuronal Monoamine-like Compound Progress in Brain Research. ,vol. 34, pp. 63- 73 ,(1971) , 10.1016/S0079-6123(08)63954-0
GG Holz, SA Shefner, EG Anderson, Serotonin decreases the duration of action potentials recorded from tetraethylammonium-treated bullfrog dorsal root ganglion cells The Journal of Neuroscience. ,vol. 6, pp. 620- 626 ,(1986) , 10.1523/JNEUROSCI.06-03-00620.1986
John Carew Eccles, The Physiology of Synapses ,(1964)
Edward F. Domino, John W. Kissel, The effects of some possible neurohumoral agents on spinal cord reflexes. Journal of Pharmacology and Experimental Therapeutics. ,vol. 125, pp. 168- 177 ,(1959)
E Sanders-Bush, P J Conn, Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. Journal of Pharmacology and Experimental Therapeutics. ,vol. 242, pp. 552- 557 ,(1987)
C.P. Vandermaelen, G.K. Aghajanian, Serotonin-induced depolarization of rat facial motoneurons in vivo: Comparison with amino acid transmitters Brain Research. ,vol. 239, pp. 139- 152 ,(1982) , 10.1016/0006-8993(82)90838-1
G. Skagerberg, A. Björklund, Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat Neuroscience. ,vol. 15, pp. 445- 480 ,(1985) , 10.1016/0306-4522(85)90225-8
R.M. Bowker, K.N. Westlund, J.D. Coulter, Origins of serotonergic projections to the spinal cord in rat: an immunocytochemical-retrograde transport study. Brain Research. ,vol. 226, pp. 187- 199 ,(1981) , 10.1016/0006-8993(81)91092-1
Z.G. Jiang, E. Shen, N.J. Dun, Excitatory and inhibitory transmission from dorsal root afferents to neonate rat motoneurons in vitro. Brain Research. ,vol. 535, pp. 110- 118 ,(1990) , 10.1016/0006-8993(90)91829-6