Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring.

摘要: Hexavalent chromium (CrVI) is a highly toxic metal and major environmental pollutant. Several studies indicate that CrVI exposure adversely affects reproductive function. We reported maternal Cr resulted in accumulation the organs of female offsprings. can cross placental barrier also be passed through breastfeeding. The present investigation aimed to determine persistent (in utero puberal period) exposure-induced effects on functions mother offspring. Induction oxidative stress one plausible mechanisms behind Cr-induced cellular deteriorations. Mother rats exposed showed reduced outcome, while offsprings higher ovary, altered steroid, peptide hormones. Specific activities antioxidant enzymes were decreased associated with increased levels H2 O2 , lipid peroxidation. damaged ovarian histoarchitecture various age groups studied. delayed sexual maturation. Results from suggest period significantly pubertal development antioxidants, anemia, hormone levels. These changes extended estrous cycle developing Wistar rats.