Biocompatibility of native and functionalized single-walled carbon nanotubes for neuronal interface.

摘要: Single-walled carbon nanotubes (SWNTs) have unique mechanical, electrical, and optical properties can be easily chemically modified; features that make them excellent candidate materials for applications as sensors stimulators in neuronal tissue engineering. The purpose of this study was to demonstrate SWNTs support attachment growth, simple chemical modifications employed control cell do not interfere with ongoing function, neurons electrically coupled SWNTs. Growth the neuroblastoma*glioma NG108, a model cell, assessed on unmodified SWNT substrates or from modified 4-benzoic acid 4-tert-butylphenyl functional groups using functionalization method. films but at reduced level compared culture-treated polystyrene. order viability culture treated polystyrene > 4-tert-butylphenyl-functionalized acid-functionalized Decreased growth after untreated (non adherent) suggested critical determinant proliferation Fluorescence scanning electron microscopy revealed decreased neurite outgrowth NG108 grown substrates. We are also among first electrical coupling by demonstrating rat primary peripheral showed robust voltage-activated currents when stimulated through transparent, conductive films. Our data suggest flexible resource engineering application involving excitable tissues such muscles nerves.