Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections

摘要: MicroRNAs (miRNAs), which are small non-coding RNAs expressed by almost all metazoans, have key roles in the regulation of cell differentiation, organism development and gene expression. Thousands miRNAs regulating approximately 60 % total human genome been identified. They regulate genetic expression either direct cleavage or translational repression target mRNAs recognized through partial complementary base pairing. The active functional unit miRNA is its complex with Argonaute proteins known as microRNA-induced silencing (miRISC). De-regulated may contribute to a diverse group disorders including cancer, cardiovascular dysfunctions, liver damage, immunological dysfunction, metabolic syndromes pathogenic infections. Current day studies revealed that indeed pivotal component host-pathogen interactions host immune responses toward microorganisms. emerging tool for study, therapeutic diagnosis infections caused viruses, bacteria, parasites fungi. Many pathogens can exploit system their own benefit such surviving inside cell, replication, pathogenesis bypassing some barriers, while express pathogen-encoded contributing survival and/or latency. In this review, we discuss role significance relation viruses.