Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare.

摘要: Scientists who perform major survival surgery on laboratory animals face a dual welfare and methodological challenge: how to choose surgical anesthetics post-operative analgesics that will best control animal suffering, knowing both pain the drugs manage can all affect research outcomes. publish full descriptions of procedures allow critical systematic reviews data, demonstrate their adherence norms, guide other scientists conduct own studies in field. We investigated what information management reasonably diligent scientist might find planning for successful experiment. To explore range fields describe this ethical concern, we scored 400 scientific articles included surgeries as part experimental methods, completeness anesthesia analgesia. The (250 accepted publication pre-2011, 150 2014-15, along with 174 they reference) thoracotomies, craniotomies, gonadectomies, organ transplants, peripheral nerve injuries, spinal laminectomies orthopedic dogs, primates, swine, mice, rats rodents. Publication Completeness (PC), which was any mention use or analgesics; Analgesia Use (AU) post-surgical analgesics, (a composite score comprising intra-operative analgesia, extended multimodal analgesia). 338 were PC. 98 these AU, some while 240 mentioned only but not Journals' caliber, measured by 2013 Impact Factor, had no effect PC AU. found whether journal instructs authors consult ARRIVE publishing guidelines published 2010 AC mouse rat our 2014-15 dataset. None 302 silent about analgesic an explicit statement withheld, discussion untreated results. conclude current literature cannot be trusted present detail analgesics. report focus more potential sources bias results, under-appreciate skew thus mostly treat solely jurisdiction care committees. At same time, regulations do include guidance even though is integral cycle building work, leaving it journals voluntarily decide details publish. suggest journals, regulators should revise regulations, treatment transparent reporting pain, improve data-quality deficiency.