Oscillating growth patterns of multicellular tumour spheroids
作者： R. Chignola , A. Schenetti , E. Chiesa , R. Foroni , S. Sartpris
DOI: 10.1046/J.1365-2184.1999.3210039.X
关键词: Gompertz function 、 Growth kinetics 、 Periodic oscillations 、 Cell culture 、 Biophysics 、 Multicellular organism 、 Tumour spheroid 、 Growth equation 、 Biology 、 Glioblastoma cell line
摘要: . The growth kinetics of 9L (rat glioblastoma cell line) and U118 (human multicellular tumour spheroids (MTS) have been investigated by non-linear least square fitting individual curves with the Gompertz equation power spectrum analysis residuals. Residuals were not randomly distributed around calculated trajectories. At one main frequency was found for all analysed MTS curves, demonstrating existence time-dependent periodic fluctuations volume dimensions. Similar oscillations dimensions also observed generated using cloned cells. However, we significant differences in obtained polyclonal Our findings demonstrate that patterns three-dimensional cultures are more complex than has previously predicted traditional continuous models.
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