Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain.

摘要: Abstract A 6.2-kb full-length clone encoding a distinct protein-tyrosine phosphatase (PTP; EC 3.1.3.48), PTPD1, was isolated from human skeletal muscle cDNA library. The encodes protein of 1174 amino acids with N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin family, which also includes two PTPs H1 and MEG1. PTP domain is positioned in extreme C-terminal part there an intervening about 580 residues without any apparent known proteins separating ezrin-like domains. Thus, PTPD1 closely related, partially characterized, PTPD2 belong same family as PTPH1 PTPMEG1, but because features constitute different subfamily. Northern blot analyses indicate that are expressed variety tissues. In transient coexpression experiments found be efficiently phosphorylated by associated src kinase pp60src.