Flow cytometric analysis of the nuclear DNA content of hepatoblastoma
作者： Yoshinobu Hata , Hiroyuki Ishizu , Kazuyoshi Ohmori , Hiromi Hamada , Fumiaki Sasaki
DOI: 10.1002/1097-0142(19911215)68:12<2566::AID-CNCR2820681206>3.0.CO;2-Z
关键词: Nuclear DNA 、 Aneuploidy 、 Fetus 、 Ploidy 、 Pathology 、 DNA 、 Hepatoblastoma 、 Flow cytometry 、 Biology 、 Dna index 、 Cancer research 、 Oncology
摘要: The nuclear DNA content of 15 hepatoblastoma cases was determined in paraffin-embedded tissues by flow cytometry. index (DI) calculated, and the ploidy pattern estimated. correlation between clinicopathologic findings studied, prognostic significance investigated. An aneuploid seen 50% lesions with histologic embryonal anaplastic types. It not fetal type. In tumors combined epithelial components, fetal-type component had a diploid all five cases. embryonal-type associated aneuploidy two tumors, vascular invasion (tumor emboli vessels) observed more frequently. prognosis patients an tumor significantly poorer. These results indicate that analysis might be useful investigating hepatoblastoma.
sci-hub.se 参考文章(15)
AT Look, PK Roberson, DL Williams, G Rivera, WP Bowman, CH Pui, J Ochs, M Abromowitch, D Kalwinsky, GV Dahl, Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia. Blood. ,vol. 65, pp. 1079- 1086 ,(1985) , 10.1182/BLOOD.V65.5.1079.1079
Kamal G. Ishak, Paul R. Glunz, Hepatoblastoma and hepatocarcinoma in infancy and childhood.Report of 47 cases Cancer. ,vol. 20, pp. 396- 422 ,(1967) , 10.1002/1097-0142(1967)20:3<396::AID-CNCR2820200308>3.0.CO;2-O
Henrik C. F. Bauer, Andris Kreicbergs, Claes Silfverswärd, Bernhard Tribukait, DNA Analysis in the differential diagnosis of osteosarcoma Cancer. ,vol. 61, pp. 2532- 2540 ,(1988) , 10.1002/1097-0142(19880401)61:7<1430::AID-CNCR2820610725>3.0.CO;2-M
C C Bird, N R Griffin, M R Howard, P Quirke, C J O'Brien, J A Child, Prognostic indicators in centroblastic-centrocytic lymphoma. Journal of Clinical Pathology. ,vol. 41, pp. 866- 870 ,(1988) , 10.1136/JCP.41.8.866
D W Hedley, M L Friedlander, I W Taylor, C A Rugg, E A Musgrove, Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry Journal of Histochemistry and Cytochemistry. ,vol. 31, pp. 1333- 1335 ,(1983) , 10.1177/31.11.6619538
Yoshinobu Hata, The clinical features and prognosis of hepatoblastoma: Follow-up studies done on pediatric tumors enrolled in the Japanese pediatric tumor registry between 1971 and 1980. Part I Surgery Today. ,vol. 20, pp. 498- 502 ,(1990) , 10.1007/BF02471004
S Kumar, HB Marsden, RA Cowan, JM Barnes, Prognostic relevance of DNA content in childhood renal tumours. British Journal of Cancer. ,vol. 59, pp. 291- 295 ,(1989) , 10.1038/BJC.1989.60
Masaharu Yasue, Tadanori Tomita, Herbert Engelhard, Frank Gonzalez-Crussi, David G. McLone, Kenneth D. Bauer, Prognostic importance of DNA ploidy in medulloblastoma of childhood. Journal of Neurosurgery. ,vol. 70, pp. 385- 391 ,(1989) , 10.3171/JNS.1989.70.3.0385
Hiroyuki Ishizu, Flow cytometric analysis of the nuclear DNA content of hepatocellular carcinoma Surgery Today. ,vol. 19, pp. 662- 673 ,(1989) , 10.1007/BF02471716
W.M. Molenaar, A. Dam-Meiring, W.A. Kamps, C.J. Cornelisse, DNA-aneuploidy in rhabdomyosarcomas as compared with other sarcomas of childhood and adolescence. Human Pathology. ,vol. 19, pp. 573- 579 ,(1988) , 10.1016/S0046-8177(88)80207-7