Antibacterial diterpenes from the roots of Salvia blepharochlaena.

作者: Ayhan Ulubelen , Sevil Öksüz , Gülaçtı Topcu , Ahmet C. Gören , Wolfgang Voelter

DOI: 10.1021/NP0004956

关键词: Antibacterial activityTerpenoidSalviaStaphylococcus epidermidisChemistryDiterpeneEnterococcus faecalisStereochemistryBacillus subtilisAntibacterial agent

摘要: The roots of Salvia blepharochlaena have yielded two new diterpenoids, blephaein (1) and O-methylpisiferic acid methyl ester (2), together with eight known diterpenoids. structures the compounds were established by spectroscopic analysis some chemical reactions. Potent antibacterial activity was exhibited horminone (9) 7-acetylhorminone (10) against Staphylococcus aureus ATCC 6538 P, epidermidis 12226, Bacillus subtilis 6633. Horminone also found to be active Enterococcus faecalis 29212.

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